Abstract: Background: Osteoarthritis, the most common form of degenerative arthroses, affects the elderly resulting in physical, mental and social distress. In this study, we compare the two different intraarticular injections (Platelet Rich Plasma vs Hylan G-F 20) efficacy on osteoarthritis management.
Aims and Objectives: To compare the outcomes of intraarticular injection of autologous platelet-rich plasma versus hyaluronic acid viscosupplementation in osteoarthritis of knee.
Materials and Methods: In this study of 60 patients with OA knee who presented to CIO OPD, Safdarjung hospital, after getting their informed consent, one group treated with PRP (group1, n= 30) and the other with Hylan GF 20 (group 2,n = 30). In group 1, patients received 3 Intraarticular injections of PRP at 4 weeks interval and in group 2, patients received a single Intraarticular injection of Hylan GF 20 (Synvisc one). Institutional ethical committee approval was obtained. SPSS version 17.0 was used for analysis.
Results: Baseline characteristics like age, sex, BMI of both groups were indifferent and comparable. Intraarticular injections of PRP and Hylan GF 20 depicted improvement in both VAS and WOMAC index. PRP had a statistically significantly better outcome than Hylan GF 20 from the fourth month of follow-up in both sexes, in both age groups and in OA grades II and III. PRP was significantly better than hylan G-F 20 from the 6th month in the BMI group of 18.5 to 24.99 and from the 5th month of follow-up in patients with a BMI more than 24.99.
Conclusion: Patients in both treatment groups showed improvement, whereas Intraarticular PRP injection group had a statistically significant better outcome than Hylan G-F 20 from the fourth month of follow up.
