Role of undenatured collagen type ii in management of osteoarthritis: A hospital based study

Author(s): Dr. Sathik Babu, Dr. Pradeep Elangovan and Dr. Dinesh Kumar S

Abstract: Osteoarthritis knee is a degenerative disease, predominantly seen in the elderly population, which caused by the destruction of the articular cartilage. The extra cellular matrix of the articular cartilage is predominantly made up of water, collagen, proteoglycans and other proteins. Altogether, these components help in maintaining its unique mechanical properties, among all the components, collagen alone makes up about 60% in extra cellular matrix, of which type II collagen alone makes up about 90% to 95%. Collagen derivatives have shown effective restriction in disease progression. This study analyses the efficacy of undenatured type II collagen in the treatment of osteoarthritis of knee. A total of 50 patient who fulfilled the inclusion and exclusion criteria, were randomly sampled in 2 groups, group A patients were treated with undenatured collagen type II and group B patients were treated with glucosamine chondroitin for 3 months. Functional outcome was measured using WOMAC score. In the initial follow up days there was minimal difference in the results between the groups. But later on, follow-up in 60 and 90 days shows significant reduction in WOMAC SCORE and VAS Score with UDC II group. Group A (UDC II) showed significant reduction in WOMAC score and effective improvement in quality of life in patients with mild to moderate osteoarthritis.

DOI: https://doi.org/10.22271/ortho.2020.v6.i4k.2414