Correlation of serum hyaluronic acid with clinical and radiological severity in primary knee osteoarthritis

Author(s): Dr. Vishnu Mittal, Dr. Anurag Chhabra, Dr. Ashok Kumar, Dr Swaranjeet Soni, Dr. Surender Singh and Dr. Yogesh Aggarwal

Abstract: Objective: To investigate relationship between serum hyaluronic acid (sHA) level and the presence and severity of radiographic knee osteoarthritis (OA) as well as degree of knee pain.
Design: A total of 150 subjects (75 controls and 75 cases) were enrolled in this study. Based on the Kellgrene Lawrence (K-L) grade, participants were radiographically classified into three groups: mild (K-L grade1 & 2), moderate ( K-L grade 3) and severe (K-L grade 4). The degree of knee pain was quantified by WOMAC knee pain score. sHA levels were compared among the controls & cases and with radiological grading. In addition, the correlation between sHA level and the degree of knee pain was analyzed in each group.
Results: In relationship between sHA level and the severity of radiographic knee OA, sHA level of the case group was significantly higher than in the normal group (P< 0.001). Furthermore, sHA level correlated with the severity of radiographic knee OA (r = 0.880). sHA level had positive correlation and significant association with WOMAC knee pain in study groups. (r = 0.750, P<0.001).
Conclusion: sHA level has the potential to be useful for the diagnosis and prognosis of the severity of primary knee OA.

DOI: https://doi.org/10.22271/ortho.2018.v4.i2g.64