International Journal of Orthopaedics Sciences

International Journal of Orthopaedics Sciences

2018, Volume 4 Issue 2

Correlation of serum hyaluronic acid with clinical and radiological severity in primary knee osteoarthritis

Author(s): Dr. Vishnu Mittal, Dr. Anurag Chhabra, Dr. Ashok Kumar, Dr Swaranjeet Soni, Dr. Surender Singh and Dr. Yogesh Aggarwal
Abstract: Objective: To investigate relationship between serum hyaluronic acid (sHA) level and the presence and severity of radiographic knee osteoarthritis (OA) as well as degree of knee pain.
Design: A total of 150 subjects (75 controls and 75 cases) were enrolled in this study. Based on the Kellgrene Lawrence (K-L) grade, participants were radiographically classified into three groups: mild (K-L grade1 & 2), moderate ( K-L grade 3) and severe (K-L grade 4). The degree of knee pain was quantified by WOMAC knee pain score. sHA levels were compared among the controls & cases and with radiological grading. In addition, the correlation between sHA level and the degree of knee pain was analyzed in each group.
Results: In relationship between sHA level and the severity of radiographic knee OA, sHA level of the case group was significantly higher than in the normal group (P< 0.001). Furthermore, sHA level correlated with the severity of radiographic knee OA (r = 0.880). sHA level had positive correlation and significant association with WOMAC knee pain in study groups. (r = 0.750, P<0.001).
Conclusion: sHA level has the potential to be useful for the diagnosis and prognosis of the severity of primary knee OA.
Pages: 420-425  |  886 Views  21 Downloads
How to cite this article:
Dr. Vishnu Mittal, Dr. Anurag Chhabra, Dr. Ashok Kumar, Dr Swaranjeet Soni, Dr. Surender Singh, Dr. Yogesh Aggarwal. Correlation of serum hyaluronic acid with clinical and radiological severity in primary knee osteoarthritis. Int J Orthop Sci 2018;4(2):420-425. DOI: 10.22271/ortho.2018.v4.i2g.64
International Journal of Orthopaedics Sciences