Abstract: Objective: The aim of this study is to find out whether urinary telopeptide measurement can diagnose osteoporosis.
Materials and Method: The study was conducted among patients who come to Sri Ramachandra hospital as inpatient or out patient during the period October 2015 to October 2017. Institutional ethics committee approval was obtained prior to the study. The inclusion criteria for the study were women aged 65 or older, Women age > 60 with risk factors, Younger postmenopausal women with one or more risk factors, (other than being female), Men aged 70 or older
and Men > 50 with risk factors and any person having fresh fragility fracture. The patients with confirmed osteopenia/osteoporosis based on DEXA scan forms the case group and age and gender matched control without osteopenia/osteoporosis forms the control group. The results from DEXA scan were taken as gold standard against urinary n telopeptide.
Results: Fifty persons had DEXA normal and became control while twenty osteopenic and forty osteoporotic persons formed the case group. We had 47 persons in cases group (Osteoporotic) having fractures and seven from control group having fracture. The mean value of urinary n telopeptide in cases and control were 182.5 and 49.8 respectively.
Conclusion: Urinary n telopeptide is a dynamic measurement of what is actually happening in bone at any given time. Hence simple urine test - Urinary n telopeptide can be used to diagnose osteoporosis.
