Vol. 11, Issue 3 (2025)

Post-operative infections remain a major complication of orthopedic surgeries, contributing to increased morbidity, prolonged hospital stays, and higher healthcare costs. This retrospective study analyzed 1,000 patients (500 upper limb, 500 lower limb) who underwent surgeries at Dr. D.Y. Patil Hospital, Navi Mumbai, between 2019 and 2022. Findings revealed a higher infection rate in lower limb surgeries (3.8%) compared to upper limb surgeries (2.5%). Lower limb procedures showed a greater proportion of deep infections, often requiring surgical intervention. Significant risk factors included prolonged operative time, diabetes mellitus, obesity, and smoking. Staphylococcus aureus emerged as the most common pathogen across both groups. These results underscore the need for preoperative optimization, adherence to aseptic intraoperative techniques, and vigilant postoperative monitoring. Establishing multidisciplinary infection control teams is recommended to guide antibiotic prophylaxis and enhance patient outcomes.