Vol. 10, Issue 4 (2024)

Rituximab versus cyclophosphamide in the management of Wegener's granulomatosis: A systematic review and meta-analysis

Author(s):

Mo’men Shabib, Osamah Al-Ramahi, Mohammad Al-Sharab, Mohammad Al-Oran and Mohammad Al-khrissat

Abstract:

Background : Wegener granulomatosis is an auto- immune disease that causes damage in blood vessels, type of Antineutrophil cytoplasmic antibody (ANCA)- associated vasculitis. The treatment by Rituximab versus Cyclophosphamide that different mechanism on CD20 on B cell and alkylating DNA due to replication dividing cells like neutrophils and lymphocytes.
Methods : We systematically searched electronic databases, including PubMed, Scopus, Elsevier and Cochrane journals, spanning from each database's inception to Aug 10, 2024.Following guidelines specifiedin the Preferred Reporting Items for Systematic Reviewsand Meta-Analyses (PRISMA), Pooled effect estimates with 95% confidence intervals will be calculated using random-effects model.
Results: Four studies have included in this meta- analysis total 504 patients after events that are evaluatingthe safety and effectiveness of Rituximab compared to Cyclophosphamide in patients with Antineutrophil cytoplasmic antibody (ANCA)- associated vasculitis and two studies focusing on patient with renal diseases.
Conclusion : This meta-analysis indicates that Rituximab has a higher mortality rate. On the other hand, Cyclophosphamide shows a higher vasculitis damage score. By Birmingham Vasculitis Activity Score for Wegener’s Granulomatosis there is no significant preference between the two drugs. It is recommended for patients with ANCA to use a different investigation to confirm from a positive result to balance efficacy and minimize harmful consequences.

Pages: 495-502  |  195 Views  104 Downloads

How to cite this article:
Mo’men Shabib, Osamah Al-Ramahi, Mohammad Al-Sharab, Mohammad Al-Oran and Mohammad Al-khrissat. Rituximab versus cyclophosphamide in the management of Wegener's granulomatosis: A systematic review and meta-analysis. Int. J. Orthop. Sci. 2024;10(4):495-502. DOI: 10.22271/ortho.2024.v10.i4g.3689