Vol. 10, Issue 4 (2024)

Platelet-rich plasma (PRP) is a biologic treatment derived from blood products, and containing concentrated growth factors, which are thought to reduce inflammation and promote healing. PRP has been described as a general term for therapy lacking standardization in its composition and administration. This study was a prospective, comparative, single blind study, carried out at Department of Orthopedic Surgery, BSMMU, Dhaka, Bangladesh from January to June 2023 with a follow up of 6 months. After institutional review board approval and informed written consent from patients, this prospective case controlled clinical study was carried out in 60 patients. A total of 60 patients presenting with complaint of chronic tendinopathy, who did not respond to conservative treatment for 3 months, were included in the study. The age group varied form 18 years to 70 years with the mean age of 44 years. Incidence of fracture was observed maximum between 30- 50 years of age. Among male were 73.3% and female were 26.7%. Mean age of male patient’s was 42.39±6.14 year. Mean age of female patient’s was 41.89±5.6 year. We encounter total twenty-two-22 patients of lateral- epicondylitis, ten-10 medial-epicondylitis, fifteen-15 rotator cuff tendinopathy and thirteen-13 patients of Achilles tendinopathy. In this study PRP prepared by drawing blood from patient, centrifuging it, PRP (3 to 10 times of the whole blood) will be injected over pathological tendon site over maximum point of tenderness, followed by immobilization of the part for 3 days, followed by eccentric loading exercise for 6 weeks and results assessed clinically, visual analogue scale at regular interval. PRP injections will be widely accepted by the patient as prepared from patients own blood and risk of adverse effect is minimal. Moreover, during degranulation, platelets release various cytokines and growth factors (vascular endothelial growth factors, platelet derived growth factors, transforming growth factors B, Insulin like growth factor 1 and hepatocyte growth factors) which promote angiogenesis, tissue remodeling, and wound healing Tendinopathies are chronic affections of the attachments of muscles to the bones.