International Journal of Orthopaedics Sciences

The breakthroughs and barriers to clinical utilization of in vivo cellular therapies in the management of osteoarthritis in humans: A review

2022, Volume 8 Issue 3

The breakthroughs and barriers to clinical utilization of in vivo cellular therapies in the management of osteoarthritis in humans: A review

Author(s): Daniel D OTOBO, Jacob O ADEFILA, Johnson YONNI, Anita A OMORUYI, Ugochukwu L EZEJIOFOR, Musa A NUHU, Hayyatudeen O TANKO, Laughter AMAMCHUKWU and Lshola A MUBARAK
Abstract: Osteoarthritis is a debilitating illness that is commonly characterized by swelling, pain, stillness and limited function of the joints. It is a degenerative disease that has affected over 7% of the world’s population and is responsible for over 2% of all DALYs. It is one of the most common clinical presentations and the most common joint pathology among adults. From non-pharmacological, to pharmacological and even surgical modalities, there are a myriad of therapies for its symptomatic treatment, but no cure. Advances in research for a cure have started exploring molecular mechanisms, such as genetics and regenerative medicine. Regenerative medicine focuses on stem cellular harvest, transplants and manipulations. Sources of MSC are currently BMSC and ADSC. Application of this therapy have moved from an invasive approach to a non-invasive approach. Recent advances in stem cell therapies have focused on MSCs, EVs and exosomes, for their effective and promising results so far. As thousands of more case studies and researches are currently going on around the world, this study will be taking a systematic look in to the breakthroughs and barriers these researchers have discovered or encountered in the course of their research and how this affects the propensity to clinical adoption and utilization of stem cellular therapies in the treatment of osteoarthritis.
Pages: 232-235  |  320 Views  54 Downloads
How to cite this article:
Daniel D OTOBO, Jacob O ADEFILA, Johnson YONNI, Anita A OMORUYI, Ugochukwu L EZEJIOFOR, Musa A NUHU, Hayyatudeen O TANKO, Laughter AMAMCHUKWU, Lshola A MUBARAK. The breakthroughs and barriers to clinical utilization of in vivo cellular therapies in the management of osteoarthritis in humans: A review. Int J Orthop Sci 2022;8(3):232-235. DOI: 10.22271/ortho.2022.v8.i3d.3204
 
International Journal of Orthopaedics Sciences
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