Abstract: Background: A correct information about the most common causative organism and it sensitivity pattern in that clinical setup is essential for designing empirical therapy. The present study has been designed to study the microbiological profile and antibiotic sensitivity pattern of post-operative orthopaedic Implant infections in a tertiary care teaching hospital.
Material and Method: This prospective observational study. Patients who presented with the signs and symptoms of infections, confirmed by laboratory and other routine investigations, were included in the present study. The demography, microbiological data sensitivity to an antimicrobial agent of organism was recorded.
Result: The most common pathogen isolated was Pseudomonas aeruginosa that is 52(43.3 %), followed by staphylococcus aureus, that is 50(41.66%). Pseudomonas aeruginosa was sensitive to Piperacillin tazobactam 42(80.7%), Imipenem 40(76.9%), Imipenem+cilastatin 42(80.7%) and Meropenem 43(82.7%). Methicillin-resistant staph aureus was sensitive to Cotrimoxazole 6(50%), Clindamycin 9(75%), Vancomycin 11(91.7%) and Linazolid10 (83.4%).
Conclusion: The implant of femur was most commonly infected. Staphylococcus Aureus (MSSA) was commonly associated with biofilm formation, followed by Staphylococcus Aureus (MRSA). Pseudomonas aeruginosa isolated from implant infections were sensitive to Piperacillin+ tazobactam, Imipenem, Imipenem+cilastatin and Meropenem.
