Vol. 5, Issue 4 (2019)

Background: Levobupivacaine and Bupivacaine are commonly used local anesthetics in regional anesthesia. While both offer effective pain control, their differences in onset, duration, and side effects may influence clinical decisions. This study aims to compare the efficacy, safety, and side effect profiles of Levobupivacaine and Bupivacaine in patients undergoing anesthesia.

Materials and Methods: A prospective, randomized study was conducted involving 60 participants, with 30 patients assigned to receive Levobupivacaine and 30 to receive Bupivacaine. Demographic data, characteristics of sensory and motor block and side effects profile were recorded. Statistical analyses were performed to compare the two groups.

Results: The results showed that Levobupivacaine had a significantly slower onset and peak time for sensory block compared to Bupivacaine (P < 0.001), but its sensory and motor blocks lasted longer. Levobupivacaine also demonstrated a more favorable safety profile with lower incidences of hypotension, nausea, and bradycardia (P < 0.05), while Bupivacaine was associated with a higher incidence of bradycardia and hypotension.

Conclusion: Levobupivacaine offers a longer duration of anesthesia with a safer cardiovascular profile compared to Bupivacaine, making it a preferred option for longer surgeries. However, Bupivacaine may be more suitable for procedures requiring rapid onset of anesthesia. Further studies are needed to confirm these findings in diverse clinical settings.