Vol. 3, Issue 4 (2017)

Abstract: Objective: Measurement of Serum Vitamin D levels in patients with knee osteoarthritis and compare with age matched healthy population in order to assess their association. Design: Prospective clinical control study. Methods: Clinically proven two hundred patients of osteoarthritis knee (OA) and two hundred control included in study according to inclusion and exclusion criteria on OPD basis after getting written and informed consent, Serum 25-OHD was measured by the ELISA method and concentrations <20 ng/ml were considered as deficient levels. Results: Four hundred subjects participated in study. The mean ages of patients and controls were 59.2 ± 12.9 and 58.9 ± 10.2 years respectively. The mean 25OHD in OA patients aged <60 years was significantly lower than controls (19.8 ± 18.8 vs. 36.7 ± 27.5 ng/ml, p< 0.01). In this age group knee OA was significantly associated with serum 25-OHD deficiency. The association between OA and serum 25-OHD deficiency in patients aged ≥60 years did not reach a significant level. Conclusions: These findings indicate a significant association between serum 25-OHD deficiency and knee OA in patients aged <60 years and suggest serum 25-OHD measurement in any patient with symptoms suggestive of knee OA particularly at the initial stage of disease.