Assessment of clinical outcomes of PRP therapy in OA knee

Author(s): Dr. Hemeshwar Harshwardhan, Dr. Hirdesh Kumar Saini and Dr. Prashant Gupta

Abstract: PRP is an autologous mixture of highly concentrated platelets and associated growth factors and other bioactive components produced by centrifugal separation of whole blood used in OA knee. The purpose of the study was to evaluate the role of PRP in management of OA knee and its clinical outcome in term of decrement in WOMAC and VAS scores up to 12 months follow up. 100 patients with150 knees (65 female, 35 male) with Kellgren-Lawrence grade 1, 2, 3 and 4 aged between 50 to 72 years evaluated between November 2017 to October 2019. All patients were treated with 4 ml of intra-articular PRP injection at day 1 and at the end of 1st, 3rd, 6th and 12 months and evaluated on each visit with WOMAC and VAS scores. Decrement in WOMAC score for KL grade 1 (44.26%), grade 2 (31.89%), grade3 (29.7%), KL grade 4 (6.57%) at the end of 12 months follow up. Decrement in VAS score for KL grade1 (57.63%), KL grade 2(42.27%), KL grade 3(28.47%), KL grade 4(3.94%) at the end of 12 months follow up. Decrement in WOMAC and VAS score were statically significant with p value (<0.05) at 12 months follow up for K.L. grade 1, 2 and 3. Decrement was not statically significant for K.L. grade 4. Our study results shows that PRP therapy is minimal invasive and effective in reduction of knee pain and stiffness and improvement in quality of life only in patients with early stages of osteoarthritis knee.

DOI: https://doi.org/10.22271/ortho.2020.v6.i1d.1862