Abstract:  The purpose of this study is to analyse the effect of single dose of zoledronic acid in treating post-menopausal osteoporosis.
Aim of the study
 To show the significance increase in bmd with zoledronic acid infusion in single dose.
Materials
 Study design - prospective study.
 Study population - patients attending opd in department of orthopaedics with osteoporosis evaluated by bone mineral density (bmd) scan in govt. kilpaukmedical college hospital.
 Duration of study – 1 year
 After patients were screened with peripheral BMD densitometry patient were selected then they were subjected to do bmd dexa scan to confirm osteoporosis.
 Those who were in osteoporotic group were included in our study.
Method
 After patient is evaluated, they were instructed to drink 500ml-1000ml of water for hydration.
 Then single dose of Zoledronic acid in 100 ml of Normal saline was infused intravenously over 15 mins.
 Patient were observed for two hours then were discharged with prophylactic Paracetamol tablets.
