Abstract: Aim: There are various medical and surgical modalities available at breaking the vicious cycle of synovitis–hemarthrosis-synovitis at an early stage of synovitis in patients of haemophilia. Our study was planned to assess the short term clinical outcome in chronic knee synovitis among haemophilia A patients treated with phosphorus-32 (P-32) radiosynovectomy.
Methods: Fifteen haemophilia A patients with chronic knee synovitis were injected with P-32 Samarium radiocolloid into the knees. These patients were clinically assessed at time of injection, at one and at three months post procedure. The parameters evaluated are the Tegner Lysholm Score (TLS), Modified Knee Society Clinical Rating System score (MKSS) and by measuring the circumference of the knee joint pre and post injection. Results: Among the fifteen haemophilia A patients studied, there was statistically significant difference in all three parameters recorded with TLS having χ2 (2) = 27.887 and p value <0.001, MKSS scores having χ2 (2) = 27.745 and p <0.001, and circumference of the knee joint showing χ2 (2) = 21.333 and p <0.001 at the end of one and three months follow up.
Conclusion: P-32 radiosynovectomy done for chronic knee synovitis among haemophilia A patients showed significant improvement in clinical parameters. Hence we suggest that this simple procedure may be added to the armamentarium of current options available for these patients.
