Osteoarthritis, a disorder of the joints which is progressive is caused by gradual loss of cartilage and is characterised by the development of bony spurs and cysts at the margins of the joints. Hyaluronic acid, a mucinous glycoprotein secreted by synovial fibroblasts is a major component of joint synovial fluid (SF). Intra-articular hyaluronan (HA) therapy has been suggested as a symptom-modifying therapy. This study aims at assessing the functional efficacy and safety of two dose intra-articular Sodium Hyaluronate 500-730 kilodalton (kDa), using the WOMAC and VAS Scores in Indian patients with grade I and II osteoarthritis of the knee over a two-month period.
Material and method: Thirty patients with osteoarthritis of knee with grade I and grade II attending the OPD of the Department of Orthopaedics in Vydehi Institute of Medical Sciences and Research center during the study period were included in this study. All patients were administered with 2 injections of intra-articular Sodium Hyaluronate 500-730 kilodalton (kDa) once a week for two weeks under strict aseptic precautions and followed up to assess the response.
Results: 24 of the 30, 80% of all subjects showed improvement of both the WOMAC and VAS scores during each follow up in the two month period following intra articular injection with hyaluronic acid.